Seronegative rheumatoid arthritis patients test negative for rheumatoid factor and anti-CCP antibodies what is rheumatoid arthritis pdf still display symptoms of rheumatoid arthritis. Seronegative rheumatoid arthritis is the diagnosis of rheumatoid arthritis without the presence of certain antibodies in the patient’s blood. What is Seronegative Rheumatoid Arthritis?
The seronegative part means they don’t possess the antibodies that seropositive patients do. Many seronegative rheumatoid arthritis patients go on to develop antibodies years after their initial diagnosis. This sometimes causes the diagnosis to change to a seropositive rheumatoid factor or anti-CPP diagnosis. This is one of the many reasons that a patient can still be diagnosed with rheumatoid arthritis even if they are seronegative. Seronegative rheumatoid arthritis patients must possess a distinct set of symptoms in order to be diagnosed.
This is because the lack of antibodies in the blood makes it more difficult to reach a rheumatoid arthritis diagnosis. Though this is not an exhaustive list, the majority of these will support a rheumatoid arthritis diagnosis. If we compare these symptoms to seropositive rheumatoid arthritis symptoms, there are many similarities. However, many patients see these symptoms evolve and change over time. It is thought that seropositive patients experience a more severe disease course than seronegative patients. But studies have also shown that in some patient cases, the progression is comparable and sometimes is there is little difference.