More research is needed to shed shared epitope rheumatoid arthritis on RA’s exact causes, which are thought to be a combination of genes and environmental factors. 163 0 16 0s16 7. 813 0 0 1 .
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47 0 0 0 13 6. 5 0 1 0 6. 3 million people in the U. However, here are some surprising facts about what is known about RA’s history, triggers, and risk factors.
David Pisetsky, MD, professor of medicine and immunology at the Duke University Medical Center, in Durham, N. In addition, the chronic inflammation associated with RA causes weight loss and loss of appetite, he says. RA doesn’t have to mean wasting away. RA diagnoses among people who are genetically susceptible to the disease. Smokers who have a genetic variant known as shared epitope have a tenfold increased risk for developing RA,» Dr. We know smoking causes heart disease and certain cancers and many other diseases, but there is surprise about its link to RA. The further you get from the equator, the higher your risk of RA.
In a 2010 study of nearly 10,000 women, RA risk was higher for those living in the Northeast and Midwestern United States, compared to women who lived west of the Rockies. The authors note that the increased risk at higher latitudes could be due to lack of sunlight, as well as other environmental factors. A 2004 study tracked more than 29,000 women and found that those with the lowest intake of vitamin D had the highest risk of developing RA. It’s not proven that the vitamin plays a role. More studies are needed to confirm the link. Harvard researchers conducted a 2009 study of more than 90,000 U. They found that women who lived within 0.