If you have RA, you’re probably very familiar with the pain and joint swelling this particular type of arthritis can cause. Go to Rheumatoid Arthritis Treatment. And if you’ve had it for some time, you may even be rheumatoid arthritis methotrexate therapy the joint deformity that can occur as rheumatoid arthritis progresses, deformity that can take a significant toll on your joint function as well as your overall quality of life.
RA usually attacks the joints of the hands and feet first, and that means even simple activities like tying a shoe, brushing your teeth, combing your hair, or getting dressed can become painful activities. Leisurely pursuits like gardening or taking long walks may have lost their appeal as well, largely as a result of the pain and inflammation these joint-based movements can trigger. One of the most popular and also most effective of these non-steroidal anti-inflammatory drugs is methotrexate, or MTX is it’s called for short. And it’s a treatment option with one of the longest and most well-established safety profiles of any rheumatoid arthritis drug on the market.
RA is an autoimmune disease, which means that it’s caused by an abnormal immune response. In a healthy immune system, special cells seek out and destroy harmful germs to prevent infection and disease. In RA specifically, immune cells attack the tissues inside the joints. Normally these tissues are there to help the joints function normally and to protect the joint surfaces from painful and destructive friction. That’s why rheumatoid arthritis has the effects it does when these joint tissues are damaged or destroyed. Among the DMARDs, methotrexate is the one treatment drug which has been around the longest. One of the primary benefits of methotrexate is that it can be combined with other drugs, including other DMARDs, to provide symptom relief when methotrexate alone isn’t enough.
It can also be combined with biologics, which are drugs designed to target specific aspects of the abnormal immune response that cause joint destruction to create a more effective treatment option. Although methotrexate has been proven as a great treatment option for rheumatoid arthritis, that isn’t why this drug was created. In fact, initially methotrexate was introduced in the 1940s as a cancer treatment drug, with doctors prescribing it to provide relief for patients with different types of cancers, such as non-hodgkin lymphoma and breast cancer. The way it works is by interfering with cancer cells’ ability to absorb and use folate. 5 million people and involves itchy, inflamed skin. Fortunately for its sufferers, numerous studies have backed using methotrexate as a suitable psoriasis treatment option.
Not only is methotrexate beneficial for people with psoriasis, it’s also helpful for those diagnosed with psoriatic arthritis. This type of arthritis is different than rheumatoid arthritis in that psoriasis generally precedes issues in the joints. In some cases though, no psoriasis-type symptoms exist at all. Studies some 10 years later discovered methotrexate was also very effective in reducing the inflammation and swelling associated with RA, after its conversion to methotrexate polyglutamate once it’s in the system. By the late 1980s, methotrexate received FDA approval for the treatment of patients with rheumatoid arthritis, which means that doctors could now prescribe it when they felt that it was a suitable treatment method. And prescribing it the doctors are.