A diagnosis of seronegative rheumatoid arthritis is more common in patients who had a recent physical trauma such as a bone fracture than a diagnosis of seropositive rheumatoid arthritis. RA who has a level of Rheumatoid factor below rheumatoid arthritis 2006 laboratory’s test criteria. Now, clinicians also test the patient’s sera to see if rheumatoid factor is an IgA or IgG type antibody. The presence of rheumatoid factor is one of 7 criteria used in the diagnosis of rheumatoid arthritis.
Other names for rheumatoid factor include rheumatoid arthritis factor or RF. In other words, the seronegative rheumatoid arthritis patient has very low or undetectable levels of rheumatoid factor. Does a seronegative rheumatoid arthritis patient always remain negative? Do seronegative patients have antibodies that react with other proteins in the damaged joints? Yes, some seronegative rheumatoid arthritis patients do. Can other arthritis diseases be diagnosed as seronegative rheumatoid arthritis?
Diagnosis of rheumatoid arthritis is based on 7 criteria, only one of them being a titer of RF. About 1 of every 7 Rheumatoid arthritis patients do not contain detectable RF and are thus named seronegative. The 100 types of arthritis have overlapping symptoms. Ankylosing spondylitis, bacteria endocarditis, calcium pyrophosphate deposition disease, gout, polymyalgia rheumatic, osteoarthritis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, septic arthritis, systemic lupus erythematosus, undifferentiated spondyloarthropathy, and viral arthritis. In summary, seronegative rheumatoid arthritis means that this RA patient does not have significant levels of rheumatoid factor.