Osteoarthritis has no specific cause. Several factors lead to the reports on arthritis of OA including excess weight, injury or overuse and genes, among others.
Various genetic traits can make a person more likely to develop OA. One possibility is a rare defect in the body’s production of collagen, the protein that makes up cartilage. This abnormality can cause osteoarthritis to occur as early as age 20. Other inherited traits may result in slight defects in the way the bones fit together so that cartilage wears away faster than usual.