Osteoarthritis clinical study

Jim is a 47 year old retired truck driver who came to see me because of severe knee pain which interferes with his favored sport, racquet ball. Jim has been to many doctors over the years who prescribed steroids, and NSAIDs type drugs giving short osteoarthritis clinical study relief. However, these drugs accelerated the joint destruction.

Next, Jim saw the top orthopedic surgeon in the area who recommended bilateral knee joint replacement as soon as possible. Now Jim is asking me  if anything could be done to avoid knee replacement surgery. There is good news, Jim, we have an excellent program that can save your knees and get you back on the racquetball court. 3 grams daily in divided doses. Jim started on his program, and 6 weeks later called the office to report how amazed he was that his pain had decreased, and he is feeling better. Maybe he wouldn’t need that knee operation after all. Most orthopedic docs who see arthritis don’t know of the pioneering work by Dr Kaufman using niacinamide, vitamin B3,  for osteoarthritis.

It is quite effective at a dose of 500 mg six times a day. Dr Kaufman reported patients had improved range of motion and reduction in pain after using Vitamin B3. I have been taking this product for my cholesterol because my doctor told me to, but the nice side effect that I got with it was that it began to help the pain of arthritis in my thumb, shoulder and hip joints. I am almost pain free now and if I stop using it within three days the pain is back again. We both take 3,000mgs daily. Elimination in the Treatment of Osteoarthritis. The mechanism explaining the therapeutic effectiveness of the vitamin was related to the raising of coenzymes NAD and NADP in the synovial fluid and within the cartilage matrix itself.

This would provide energy and nucleic acids through non-oxidative processes, which is vital for cartilage repair in the deeper layers of the matrix and might have the net effect of increasing cartilage repair rates. 250 mg in tablet form, taken anywhere from 3-16 times each day, depending on the severity of OA. 500 mg niacinamide tablets six times each day. The effect of niacinamide on osteoarthritis: a pilot study. Jonas WB1, Rapoza CP, Blair WF. To evaluate the effect of niacinamide, on selected parameters of osteoarthritis using a double-blind, placebo controlled study design.

METHODS:Seventy two patients with osteoarthritis were randomized for treatment with niacinamide or an identical placebo for 12 weeks. Outcome measures included global arthritis impact and pain, joint range of motion and flexibility, erythrocyte sedimentation rate, complete blood count, liver function tests, cholesterol, uric acid, and fasting blood sugar. Compliance was monitored with a pill record sheet and interview. CONCLUSION:This study indicates that niacinamide may have a role in the treatment of osteoarthritis. Niacinamide improved the global impact of osteoarthritis, improved joint flexibility, reduced inflammation, and allowed for reduction in standard anti-inflammatory medications when compared to placebo.

More extensive evaluation of niacinamide in arthritis is warranted. A recent double-blind study confirms the efficacy of niacinamide in OA. II collagen, is crucial to the pathogenesis of OA. IL-1-exposed chondrocytes, blunting the anti-anabolic impact of IL-1. The chondroprotective antibiotic doxycycline may have a similar mechanism of action. Other nutrients reported to be useful in OA may likewise intervene in the activity or synthesis of IL-1. IL-1 in chondrocyte cell cultures, and has documented therapeutic efficacy when injected intra-articularly.

OA, upregulates the proteoglycan synthesis of chondrocytes, perhaps because it functions physiologically as a signal of sulfur availability. SAM may compensate for this deficit. Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide in osteoarthritis: a pilot study. William Kaufman had already published, 47 years earlier, his meticulous case notes for hundreds of patients, along with specific niacinamide dosage information applicable to both osteoarthritis and rheumatoid arthritis. In addition, the doctor added some remarkably prescient observations on the antidepressant-antipsychotic properties of B-3. Kaufman, whom his widow has described as a conservative physician, was nevertheless the first to prescribe as much as 5,000 mg niacinamide daily, in many divided doses, to improve range of joint motion.