There are four compartments to the knee. These are the medial and lateral knee ankle joint pain compartments, the patellofemoral compartment and the superior tibiofibular joint.
The components of each of these compartments can suffer from repetitive strain, injury or disease. Running long distance can cause pain to the knee joint, as it is high-impact exercise. Hemarthrosis tends to develop over a relatively short period after injury, from several minutes to a few hours. A Chinese study concluded that knee pain is significantly more prevalent in people working in cold stores than in those in normal temperature. A lower level of physical activity and a work environment where one is required to sit in a chair during the work day is one reason for developing knee joint pain, as the lower degree of physical movement tends to weaken the knee muscles. Blood vessels also can be affected, leading to development of painful conditions.