DRB1 is present in all individuals. Allelic variants of DRB1 are hla drb1 rheumatoid arthritis with either none or one of the genes DRB3, DRB4 and DRB5.
There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis». Genetics of inflammatory bowel disease: the role of the HLA complex». HLA-DR15 haplotype and multiple sclerosis: a HuGE review». This page was last edited on 26 October 2017, at 22:41.
Identification of these antigens has led to greater success and longevity in organ transplant. Good matching of these antigens between host and donor are most critical for achieving graft survival. HLA-DR is also involved in several autoimmune conditions, disease susceptibility and disease resistance. HLA-DR molecules are upregulated in response to signalling. DR molecule and presented to a few of a great many T-cell receptors found on T-helper cells. These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation.