Find more resources glucosamine sulphate osteoarthritis the Cochrane Community. In the broader healthcare context it refers to any attempt to synthesise the results of more than one study on a particular topic area.
The term research means different things to different people, but is essentially about finding out new knowledge that could lead to changes to treatments, policies or care. The attempt to derive generalisable new knowledge by addressing clearly defined questions with systematic and rigorous methods. What is osteoarthritis and glucosamine? In OA, the cartilage that protects the ends of the bones breaks down and causes pain and swelling. Glucosamine can be found naturally in the body and is used by the body as one of the building blocks of cartilage. Glucosamine can also be taken as a pill as a supplement to the diet, or sometimes as an injection.
The usual dose recommended on packages is 1500 mg per day or 500 mg three times a day. In Europe, glucosamine is prescribed by health care providers. But in North America, people can buy glucosamine supplements without a prescription. This means that, in North America, glucosamine is not regulated and the pills may or may not truly contain the amount described on the label. Pain: The high quality studies showed that pain improved about the same whether people took glucosamine or fake pills. People who took fake pills had a pain score of 7 points on a 0 to 100 scale.
Pain may improve by 10 more points with glucosamine than with fake pills. People who took fake pills had a pain score of 6 points on a 0 to 20 scale. People who took the Rotta brand of glucosamine rated their pain 3 points lower than people who did not take glucosamine. Function: The high quality studies show that glucosamine improved function more than fake pills when measured by one type of scale, but improved the same amount as fake pills when measured by another scale. People who took fake pills had a function score of 22 points on a 0 to 68 scale. People who took the Rotta brand of glucosamine had their ability to function improve by 2 points compared to people who did not take glucosamine.
There was no difference in the number of people who had side effects. Side effects mainly included stomach upset and other joint pain. This is a process used in studies that involve different groups receiving different interventions or treatment. Ideally, allocation to the different groups is done in such a way that the participants, and the health care providers, do not know which intervention the participant is to receive. The intention is to avoid bias during the allocation process so that the intervention and control groups are as similar as possible. An intervention that to all intents and purposes appears to be the same as that which is being assessed but which does not have the active component being assessed. 2001 and previously updated in 2005.
A method based on chance alone by which study participants are assigned to a treatment group. Randomization minimizes the differences among groups by equally distributing people with particular characteristics among all the trial arms. The researchers do not know which treatment is better. From what is known at the time, any one of the treatments chosen could be of benefit to the participant. The ability of an intervention to produce a desired effect in an individual.
The degree or strength of a poison. One of the databases in The Cochrane Library. It brings together all the currently available reviews and protocols for Cochrane Reviews. It is updated quarterly, and is available via the Internet and CD-ROM. An American based electronic database listing articles of biomedical research from a pre-determined range of peer-reviewed publications.