EULAR and ACR jointly funded and collaborated on creating a set of criteria that can be eular osteoarthritis knee to more accurately identify patients with SLE for inclusion in clinical trials. Testing of these new criteria demonstrated high sensitivity and specificity. The following article features coverage from ACR 2017 in San Diego, California.
In the past, investigative groups have favored either the EULAR or ACR criteria, making comparison of the results of various studies challenging. Sindhu Johnson, MD, PhD, director of the Toronto Scleroderma Program at the University of Toronto. We have come to appreciate potential biases that may reduce the validity or reliability of classification criteria, and as a consequence, both organizations have put out position papers on the standards we must consider when we develop classification criteria. As a result, Dr Johnson said, EULAR and ACR jointly funded and collaborated on creating a set of criteria that can be used to more accurately identify patients with SLE for inclusion in clinical trials. Phase 1 involved item identification.
Using 4 studies, 144 candidate criteria were nominated. A cross-sectional survey of patients with lupus was also conducted, in which patients were asked about early symptoms of the disease. Phase 2 reduced these 144 candidate criteria down to 40 items. Phase 3 then weighted items and identified thresholds. We realize that not all criteria are equal. Phase 4 involved fine tuning and final validation of this body of work.
The criteria were tested on 500 patients with SLE from 36 lupus centers and 500 controls. Compared with previous classifications of lupus, sensitivity was improved, and excellent specificity was maintained. What Does the New Criteria System Look Like? Right now, we have an entry criterion of an antinuclear antibody titer of 1:80 by immunofluorescent testing If a patient has that, additive criteria — including clinical domains and immunologic domains — are considered,» Dr Johnson said. Within these domains, there are subdomains weighted from lowest to highest. Within any one domain, only the criterion with the highest score may be counted.