Diacerein in osteoarthritis

Find more resources in the Cochrane Community. What is osteoarthritis and what is diacerein? In OA, the cartilage that protects the diacerein in osteoarthritis of the bones breaks down, causing pain and swelling. OA can affect any joint, but the knees, hips and hands are the joints most often studied in clinical trials.

60 or older have pain or disability from OA. Diacerein is a slow-acting drug taken as a pill that may slow the breakdown of cartilage and relieve pain and swelling. In the broader healthcare context it refers to any attempt to synthesise the results of more than one study on a particular topic area. Pain may improve slightly more in people taking diacerein. An intervention that to all intents and purposes appears to be the same as that which is being assessed but which does not have the active component being assessed. This may have happened by chance. Diacerein may slow the process of joint space narrowing slightly of the hip but may have little or no difference on the knee joint as it is seen on an x-ray.

Diacerein may cause side effects in the lower digestive tract, such as diarrhoea. The term research means different things to different people, but is essentially about finding out new knowledge that could lead to changes to treatments, policies or care. The attempt to derive generalisable new knowledge by addressing clearly defined questions with systematic and rigorous methods. People who took diacerein rated their pain to be 34 on a scale of 0 to 100 after taking the medication compared to people who took a fake pill and rated their pain to be 43 points on a scale of 0 to 100. People who took diacerein rated their physical function to be 0. People who took diacerein rated their physical function to be 9. 3 on a scale of 0 to 24 after taking the medication compared to people who took a fake pill and rated their physical function to be 9 points on a scale of 0 to 24.

42 of every 100 people who took diacerein experienced reduction in joint space narrowing of at least 0. 5 mm compared to 49 of every 100 people who took a fake pill. These drugs provide pain relief and reduce inflammation, but are not members of the narcotic group of painkilling drugs. 36 of every 100 people who took diacerein experienced diarrhoea as a side effect compared to 10 of every 100 who took a fake pill. Diarrhoea was the most common side effect and usually occurred during the first two weeks after the start of diacerein. Europe because of harms outweighing benefits.

However, this guidance is not final as the PRAC recommendation will be re-examined. The ability of an intervention to produce a desired effect in an individual. We confirmed that symptomatic benefit provided by diacerein in terms of pain reduction is minimal. The small benefit derived in terms of joint space narrowing is of questionable clinical relevance and was observed only for OA of the hip. An adverse effect may be caused by administration of a medication or by exposure to a chemical and be indicated by an untoward result such as by illness or death.