Their release has an cytokine and arthritis on the behavior of cells around them. Their definite distinction from hormones is still part of ongoing research.
Some cytokines enhance or inhibit the action of other cytokines in complex ways. 1957 as a protein that interfered with viral replication. 1966 by John David and Barry Bloom. In 1969 Dudley Dumonde proposed the term «lymphokine» to describe proteins secreted from lymphocytes and later, proteins derived from macrophages and monocytes in culture were called «monokines».
As scientists learned more, it was understood that these proteins and others were part of a broader class of proteins involved in self-defense, and should be called «cytokines». 1,000-fold during trauma or infection. The widespread distribution of cellular sources for cytokines may be a feature that differentiates them from hormones. As of 2008, the current terminology refers to cytokines as immunomodulating agents. However, more research is needed in this area of defining cytokines and hormones.