Please forward this error screen to 70. Initially, symptoms may occur only following exercise, but over time may become constant. The most commonly involved joints are those near the ends of the classification osteoarthritis, at the base of the thumb, neck, lower back, knee, and hips.
Joints on one side of the body are often more affected than those on the other. Usually the symptoms come on over years. It can affect work and normal daily activities. Osteoarthritis is believed to be caused by mechanical stress on the joint and low grade inflammatory processes. It develops as cartilage is lost and the underlying bone becomes affected.
Weight loss may help in those who are overweight. An artificial joint typically lasts 10 to 15 years. United States, 30 to 52. 5 million people are affected. It becomes more common in both sexes as people become older.
Stiffness is most common in the morning, and typically lasts less than thirty minutes after beginning daily activities, but may return after periods of inactivity. Occasionally, the joints may also be filled with fluid. Some people report increased pain associated with cold temperature, high humidity, or a drop in barometric pressure, but studies have had mixed results. Damage from mechanical stress with insufficient self repair by joints is believed to be the primary cause of osteoarthritis. Nor has cracking one’s knuckles been found to play a role. Although a single factor is not generally sufficient to cause the disease, about half of the variation in susceptibility has been assigned to genetic factors. As early human ancestors evolved into bipeds, changes occurred in the pelvis, hip joint and spine which increased the risk of osteoarthritis.
Additionally genetic variations that increase the risk were likely not selected against because usually problems only occur after reproductive success. The development of osteoarthritis is correlated with a history of previous joint injury and with obesity, especially with respect to knees. Since the correlation with obesity has been observed not only for knees but also for non-weight bearing joints and the loss of body fat is more closely related to symptom relief than the loss of body weight, it has been suggested that there may be a metabolic link to body fat as opposed to just mechanical loading. Changes in sex hormone levels may play a role in the development of osteoarthritis as it is more prevalent among post-menopausal women than among men of the same age. Increased risk of developing hip osteoarthritis over time was found among those who work in bent or twisted positions.