It may also be useful for apremilast psoriatic arthritis immune system related inflammatory diseases. It is taken by mouth. Depression: Worsening depression, suicidal thoughts, and other mood changes may occur with apremilast.
Weight loss: Weight loss has been associated with apremilast. In inflammatory cells, PDE4 is the dominant enzyme responsible for this reaction. The importance of these individual factors for the clinical effect of apremilast is not clear. II than the crystal form B. Otezla is available in the U.
22,500 for a year of treatment. This page was last edited on 21 October 2017, at 16:08. Severe psoriatic arthritis of both feet and ankles. Note the changes to the nails.
This type does not occur in the same joints on both sides of the body and usually only involves fewer than 3 joints. This condition can progress over months or years causing severe joint damage. Nail changes are often marked. Pain, swelling, or stiffness in one or more joints is commonly present in psoriatic arthritis. Psoriatic arthritis is inflammatory, and affected joints are generally red or warm to the touch.
In addition to affecting the joints of the hands and wrists, psoriatic arthritis may affect the fingers, nails, and skin. Psoriasis classically presents with scaly skin lesions, which are most commonly seen over extensor surfaces such as the scalp, natal cleft and umbilicus. Along with the above-noted pain and inflammation, there is extreme exhaustion that does not go away with adequate rest. The exhaustion may last for days or weeks without abatement. Psoriatic arthritis may remain mild or may progress to more destructive joint disease. Periods of active disease, or flares, will typically alternate with periods of remission. X-ray gives a «pencil-in-cup» appearance.